Giuliana Rancic Says She and Bill Lost Their Last Embryo

The fertility struggles of Giuliana and Bill Rancic are a long and well-documented saga. Sadly, it continues. The couple was recently dealt another devastating blow when they lost their last viable embryo to a miscarriage.

Giuliana told People that she and Bill learned on New Year's Eve that the surrogate who was carrying their third and final embryo suffered a miscarriage.

"It was painful," Rancic told the magazine. "We were so optimistic with this last embryo. We thought, 'This is definitely going to work. This is our last shot.'"

Giuliana Rancic and her son Duke (Instagram)
Giuliana Rancic and her son Duke (Instagram)

Giuliana chose to freeze four embryos when she was diagnosed with breast cancer in 2011. The first resulted in a successful pregnancy; Bill and Giuliana's son Duke was born via surrogate in 2012. Two more eggs were implanted in a surrogate in 2014, but she miscarried. Rancic calls this latest loss "the toughest blow."

Giuliana has had trouble becoming pregnant herself since 2009 when the two began trying to have a child. To become pregnant now would be extremely risky due to cancer-suppressing medication the Fashion Police host is still taking.

"We’re open to everything," Rancic says of her next move. "I think adoption is a beautiful gift you're giving each other. And it's funny, I'm even more open to [adoption] than I was before. Because I think to myself, 'I love Duke so much, if I couldn't take care of him, I hope there would be someone else who would love him.'"

Bill and Giuliana Rancic (Getty Images)
Bill and Giuliana Rancic (Getty Images)

Elsewhere in the magazine, Rancic also admits she's very aware of the recent criticism of her weight and, to an extent, she agrees. While she says that criticism and speculation about an eating disorder is "a horrible way to approach it," she also sees that she's "really thin."

The reason for her thin appearance, she claims, is those cancer-suppressing meds.

"It's really hurtful," Rancic says. "I'm sorry that some people think I'm 'disgustingly skinny,' as they put it, but there's nothing I can do. I'm lucky that I even have the type of cancer that reacts to the medicine."

She even says a nameless major publication was interested in featuring her but later backed out, saying she was "too skinny."

"That was really hurtful," she shares. "I thought, 'Wow, I'm on cancer medication. I'm doing the best that I can.'"